Sometimes, but VPNs often make P2P connection and latency worse.
Answer
Refl may still connect while a VPN is active, but VPNs often make direct connection and latency worse. If you have any problem, disabling the VPN should be one of the first things to try.
Common VPN-related issues
The session does not connect
Connection takes longer than usual
Latency or stutter becomes worse
What to try
1. Temporarily disable the VPN 2. Reconnect both devices to the same WiFi 3. Reload the page and use a fresh QR code
Notes
Corporate VPNs are especially likely to be restrictive
If stability matters, use a trusted WiFi network without a VPN whenever possible